Symptoms of High Cortisol/Stress
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Watch the previous video ‘Signs and Symptoms of Low Cortisol (Stress Science)’
High cortisol can destroy your health. Find out the major signs and symptoms of high cortisol and how it can lead to poor health.
Chronically elevated cortisol levels now causes damages on hippocampal and cortical neurons.
Cortisol, a steroid hormone, is synthesized from cholesterol. It is synthesized in the zona fasciculata layer of the adrenal cortex. Adrenocorticotropic hormone (ACTH), released from the anterior pituitary, functions to increase LDL receptors and increase the activity of cholesterol desmolase, which converts cholesterol to pregnenolone and is the rate-limiting step of cortisol synthesis. The majority of glucocorticoids circulate in an inactive form, bound to either corticosteroid binding globulin (CBG) or albumin. The inactive form is converted to its active form by 11-beta-hydroxysteroid dehydrogenase 1 (11-beta-HSD1) in most tissues, while 11-beta-HSD2 inactivates cortisol back to cortisone in the kidney and pancreas.
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